Naturalists with a deep interest in reptiles like to dig into issues and discover all the complexity. However, the average person might like a more easily digestible answer. “Is it venomous or not?” When they ask it, most folks are asking, “If I were bitten by this snake, would I have medically serious consequences?” The answer might not be as simple as we would like. I want to take a look at what happens when a gartersnake or hog-nosed snake bite causes symptoms of mild envenomation.

“A gartersnake?” you say. “What could be more harmless than a gartersnake?” Generally speaking, I agree, and so do untold numbers of kids who catch them out in a meadow or woodland edge as they learn about the natural world. I would not worry about my granddaughter or anyone else’s kid picking up a gartersnake (assuming it really is identified correctly). But are they venomous?
First, we should quickly review some information about the snakes everyone agrees are venomous. In the United States, that includes the pit-vipers (rattlesnakes, copperheads, and cottonmouths) and the coralsnakes. These snakes have fangs in the front of their mouths, and venom glands that connect with those fangs so that the snake can inject venom during a bite.
All of this came about in their evolution as a tool for subduing what they eat. A rattlesnake bites a rat and releases it. Letting go minimizes the counterattack from the rat, and the venom quickly subdues and kills the rat so that it cannot get far away. It’s easy to track it down and eat it. A coralsnake bites a small ratsnake, and its neurotoxic venom induces paralysis, making it easier prey for the coral snake.
But when threatened or attacked, biting the attacker is a natural response by the snake, and the venom of pit-vipers and coralsnakes makes that bite a more potent weapon. And so that is a second evolutionary advantage of having powerful venom and the glands and fangs to deliver it.
These are front-fanged snakes, but there are some species with enlarged teeth toward the back of the mouth and venom with some degree of toxicity. In the U.S., some of these are small snakes that pose no risk to humans, such as black-headed snakes (genus Tantilla) and night snakes (genus Hypsiglena). The hog-nosed snakes (genus Heterodon) are larger but almost always unwilling to bite. Because it is nonaggressive, the western hog-nosed snake is a very popular pet, despite being rear-fanged and having what is regarded as mild venom.
Other snakes followed different evolutionary paths for food-getting. Some, like the kingsnakes and ratsnakes (as well as boas and pythons), became constrictors. These muscular snakes bite a prey animal and very quickly wrap several coils around the animal’s body. This immobilizes the prey to keep it from getting away or counterattacking, and it quickly causes circulatory and respiratory arrest. With strong constrictors, the pressure on the prey’s body prevents the blood from circulating, which leads to a quicker death than simply being unable to breathe. Snake species that are good at constriction usually have little need for venom – but if you look hard there are exceptions to almost every rule (find some of them here).
Because snakes have no limbs or claws to tear prey apart, and mouths and teeth designed for holding on rather than for cutting and tearing, you would think that all of them need some kind of advantage like venom or constriction. However, there are snakes whose approach to hunting seems to be to chase it down and simply swallow it, while maybe using a loop of the body to hold the prey animal still. Examples would include coachwhips or the gartersnakes and watersnakes and some others in the U.S.
But sometimes it is not as simple as that. Many of our “harmless” snakes have a gland running under the upper lip from the eye back to the corner of the mouth which secretes toxins. It is called Duvernoy’s gland, and herpetologists consider it to be homologous to the venom glands of pit-vipers and the coralsnake. That is, they think it has a similar evolutionary origin to venom glands. However, Duvernoy’s gland does not store a volume of venom, nor does it empty through a duct associated with fangs or enlarged teeth.
Venom researcher Bryan Grieg Fry argues that the Duvernoy’s secretions are used to help subdue prey and because they are produced in a specialized oral gland, the right name for the secretions is “venom” and the correct name for the gland ought to be “venom gland.” Sometimes what is correct biologically may be confusing to the public.

Here’s what I mean: The average person divides snakes into a simple binary, venomous or non-venomous. When we start talking about gartersnakes with venom glands, there is going to be a lot of “wait a minute!” We have to go back and try to insert some shades of gray in those black and white distinctions between venomous and non-venomous. And some might think it’s only an academic point, that it doesn’t really matter because whatever the gartersnakes might secrete, it must be mild because people handle these snakes and are sometimes bitten, almost always with no ill effect. And the hog-nosed snakes bluff in a threatening way, but they don’t bite people. So Duvernoy’s glands or venom glands or whatever we call them are only academic details, right?
Duvernoy’s gland secretions occasionally have real impacts on human handlers. There is a report from 1985 of a 13-year-old child who developed swelling and bruising of the bitten hand after a “prolonged” bite from an eastern gartersnake (Thamnophis s. sirtalis). I suppose the bite was prolonged because the child was not afraid and was either curious or afraid of harming the snake. In any case, vital signs and laboratory tests were normal and the child quickly recovered. A 1994 report described a person bitten by a wandering gartersnake (Thamnophis elegans vagrans) who developed local swelling, bruising, and small blisters containing blood or serous fluid. Systemic signs and symptoms did not develop, that is, the symptoms were confined to the area near the bite.

In 2009, a report described a person bitten while feeding their pet western hog-nosed snake (Heterodon nasicus). Such snakes often have a strong feeding response and will try to chew and swallow a hand if it is holding the prey item. The snake held on to the person’s arm for several minutes, with resulting swelling, bruising, swollen lymph nodes, “cutaneous signs suggestive of mild cellulitis and blister formation.” The patient recovered completely after about five months. Reviewing other such bites, the authors concluded that western hog-nosed snakes should be considered capable of inflicting medically significant bites but should not be considered dangerous.
A later (2019) report described another feeding bite from a western hog-nosed snake. A 20-year-old female was bitten, “causing local symptoms and thrombocytopenia.” On the third day after the bite, the patient came in with pain, swelling, and blisters. She had a very low platelet count, that is, thrombocytopenia. The symptoms in the bite area peaked on the seventh day after being bitten, and those symptoms as well as the platelet count improved within four months after the bite. This was the first reported case of hematologic toxicity (systemic effects on the blood) from a North American colubrid snake. (A technical note: in recent years, hog-nosed snakes have been moved from Colubridae to a separate family of rear-fanged snakes, Dipsadidae.) Again, this is a species that may bite in a feeding context but almost never bites in an encounter in the wild.
A report from 2026 described a survey disseminated via personal contacts and social media asking about bites by the western hog-nosed snake. Of the 91 replies, 63 were able to be used. All 63 incidents involved captive pet snakes, with bites occurring during handling or feeding. When bites were extended or involved chewing, there was a greater chance of symptoms. The authors ranked the symptoms according to the percent of respondents who said they experienced them. People reported swelling in 79% of cases. Decreasing percentages of people reported pain, itching, stiffness, red and discolored skin, bleeding, burning sensation, numbness, and then a few cases of nausea, weakness, blistering, and scabbing. Seven respondents in this study sought medical treatment and reportedly were, in some cases, given antihistamines or steroids. (Snake bite experts remind us that symptoms of snake envenomation are not allergy-based, and so antihistamines like Benadryl are not helpful.) Most symptoms resolved within approximately a week, but two cases took longer.

What do we make of all this, apart from the conclusion that there is wonderful, fascinating complexity in the natural world? On a practical level, there are a couple of reasons to share this information. One is to help the public with those shades of gray between “venomous” and “non-venomous,” and the other is to suggest a little bit of caution to those who keep hog-nosed snakes as pets.
Without some introduction to this part of snake biology, the average person might hear about some of our “harmless” snakes having venom and (1) have their prejudices confirmed – “See, I told you that there’s no good snakes” – or (2) react to snakes with an even greater degree of unnecessary fear. Reports of medical symptoms from bites of gartersnakes are rare, mild, and temporary. Most of the rear-fanged snakes in the U.S. (nightsnakes, ring-necked snakes, black-headed snakes, etc.) are very small, making bites from them improbable. And I’m not aware of any wild hog-nosed snake ever biting someone when encountered in the wild. These snakes do deserve to be called harmless.
That brings us to the issue of keeping western hog-nosed snakes as pets. I have kept them and have had them try to chow down on my finger while feeding them. They are completely inoffensive but easily mistaken at feeding time. If I currently had one, I would not use it in educational presentations in which people are allowed to touch the snake. And I would not offer food by hand, nor would I allow the snake to chew on me, should a bite occur. Like many other snakes, they are harmless depending on what we do with them.


































